Infantile Hypoglycaemia

Persistent hyperinsulinemic hypoglycaemia followed as benign infantile convulsion

An 18-month-old boy developed seizures at 3 months of age. He developed normally and, his EEG and brain CT revealed no abnormal findings. The blood sugar level was normal at that time, thus he was diagnosed as having benign infantile convulsion. At 7 months of age seizures reappeared, and hypoglycaemia associated with hyperinsulinism was observed during the seizures. With conservative therapy h...

Infantile Hypoglycaemia due to Inherited Deficiency of Glycogen Synthetase in Liver.

In 1909 Garrod introduced the concept of the metabolic block. Over 70 diseases are now thought to be due to inborn errors of metabolism, and of these some 20 have been shown to be due to a single enzyme defect. We now report the clinical condition resulting from the congenital absence of the liver enzyme glycogen synthetase. Our report is based on the study of identical twins who become hypogly...

Hypoglycaemia unawareness.

Hypoglycaemia is the most frequent and serious complication of insulin therapy and is three times more common in those who are intensively treated. Impaired awareness of hypoglycaemia is a major limitation to achieving tight diabetes. Asymptomatic biochemical hypoglycaemia occurs more frequently during routine blood glucose monitoring and this should alert the clinician that the individual is d...

Infantile autism or infantile psychoses.

Until recently the situation in relation to childhood psychoses was extremely confused. There was little agreement among authors about terminology and a general uncertainty about their nature and aetiology. Masterly reviews by Eisenberg' 2 in the United States and Rutter' in the United Kingdom have brought some order to this complex field. Perhaps the most important contribution was the introdu...

Sulphonylureas and hypoglycaemia.